Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles
BACKGROUND This study explored the pharmacokinetics, tissue distribution, and excretion profile of zinc oxide (ZnO) nanoparticles with respect to their particle size in rats. METHODS Two ZnO nanoparticles of different size (20 nm and 70 nm) were orally administered to male and female rats, respectively. The area under the plasma concentration-time curve, tissue distribution, excretion, and th...
متن کاملPharmacokinetics, tissue distribution, and excretion of salidroside in rats.
The present study investigated the pharmacokinetics, excretion, and tissue distribution of salidroside, a main active constituent in the roots of Rhodiola species. The plasma concentration declined rapidly following the intravenous dosing at 7.5, 15, and 30 mg/kg with a short half-life time of about 1 h. The mean values of area under the concentration-time curve (300.48 ± 36.73, 514.51 ± 134.99...
متن کاملPharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats.
The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide, a cyclooxygenase-2 inhibitor, were investigated in rats. Celecoxib was metabolized extensively after i.v. administration of [(14)C]celecoxib, and elimination of unchanged compound was minor (less than 2%) in male and female rats. The o...
متن کاملAssessment of antioxidant and antibacterial activities of Zinc Oxide nanoparticles, Graphene and Graphene decorated by Zinc Oxide nanoparticles
Zinc Oxide nanoparticles (ZnO-NPs) and graphene carbon material, due to lower drug resistance, can replace antibiotics, and by decorating of graphene with Zn-NPs, their properties can be greatly improved. The purpose of this study was to evaluate the antioxidant and antibacterial effects of ZnO-NPs biosynthesized using Crocus Sativus petal extract, graphene and graphene decorated by ZnO-NPs bio...
متن کاملBiosensor using Zinc Oxide Nanoparticles
A novel technique for glucose sensing using collagen based thin film and zinc oxide (ZnO) nanoparticles, the Zinc Oxide Collagen Glucose Sensor (ZnOCGS) presented here. The Zinc oxide is synthesized using the two medium namely treating with 1.Ethanediol medium (Ethylene glycol) and 2.Water medium. It is characterized using the analytical techniques such as Fourier Transform infrared spectroscop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2012
ISSN: 1178-2013
DOI: 10.2147/ijn.s32593